Senior Engineer

Intabio, Inc. is a Series A funded, early stage company developing analytical solutions to transform biotherapeutic development and manufacturing with products that provide early product quality characterization and profound efficiency gains across all stages of biopharmaceutical development and manufacturing. Intabio's first product, the Blaze system, will provide rapid detection and identification of subtle protein modifications - modifications that can undermine the stability and efficacy of biotherapeutic drugs such as monoclonal antibodies and recombinant proteins. Our innovative core technology is the first to utilize microchip functionality to integrate (1) separation of protein isoforms by capillary isoelectric focusing, (2) 280-nm imaging of protein isoforms for quantitation, and (3) electrospray ionization for delivery of the separated isoforms to an adjacent mass spectrometer.

 

Intabio, Inc. has an immediate opening for a Senior Engineer in Newark, CA. This high-impact individual will  be part of the engineering team developing Intabio’s first commercial platform, an analytical system that utilizes a proprietary microchip technology to separate, quantitate, and transfer intact biotherapeutic proteins by electrospray into a mass spectrometer (MS) for molecular identification. The Senior Engineer be a key team member designing the Blaze instrument and cartridge.

 

Key Responsibilities:

  • Design of instrument and cartridge systems, subsystems.

  • Drive testing and verification activities.

  • Work closely with microfluidics design team and vendors.

  • Transfer to manufacturing instrument systems and cartridges.

  • Tightly manage development projects contracted to external design firms.

  • Provide technical and scientific guidance to address engineering challenges.

  • Help implement a stage gate product development process.

 

Qualifications:

  • BS and 10 years’ experience, or PhD and 5 years or equivalent in Engineering, Chemistry, Materials Sciences or Physics or equivalent experience

    • Development of liquid handling systems.

    • Development of plastics consumables.

    • Workflow optimization.

    • Complex platform and system engineering.

    • Track record of successful launch of a complex consumable and instrument.

  • Experience with Solidworks a must.

  • Experience of prototyping and manufacturing methods of various biochemical compatible plastic materials.

  • Experience with automation systems and mechatronics.

  • Experience managing projects with commercial design houses.

  • Experience with analysis tools such as Matlab, r and JMP a plus

  • Experience with automation tools such as Labview and Python a plus.

  • Experience using product development processes and tools to drive and manage product development, including a phased product development process, a design review process, FMEA, and Microsoft Project.

  • Familiar with common protein analysis methods such as cIEF, CE, Mass Spectroscopy, Western blotting and sizing.

  • Experience in managing and leading cross-functional project teams.

  • Have strong knowledge of Systems Design for Six Sigma (DFSS)

 

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